Anywhere opioids are present, so is the risk for an opioid overdose1
There are risks with taking prescription opioid painkillers, even when they are taken correctly.
42,000 deaths due to opioids in 2016—40% involved prescription opioid painkillers2
~85% of deaths from opioid painkillers are accidental2
>6,000 children 0 to 5 years of age accidentally come in contact with opioids each year3
Teenagers (13-19 years of age) are the age group with the second highest number of opioid exposures among children <20 years of age3
Know the risk factors
The risk of having an opioid overdose can increase for a number of reasons:
Increasing doses of opioids4,5
A medical condition that affects your breathing, liver, or kidneys6
Taking opioids and drinking alcohol or taking opioids at the same time as certain anxiety and sleep medications6,7
Having a history of substance use disorder8
Having opioids in your home, which may put others at risk (eg, children or teenagers)3
That is why the Surgeon General of the United States cautioned:
“For patients currently taking high doses of opioids as prescribed for pain… knowing how to use naloxone and keeping it within reach can save a life.”9
EVZIO—an auto-injector designed to be easy to use—provides simple, on-the-spot voice and visual guidance to help those with no medical training administer naloxone during an opioid overdose.
EVZIO is not a substitute for emergency medical care.
Talk to your healthcare professional to learn more about EVZIO.
You also can call 1-855-77-EVZIO (1-855-773-8946) for more information about EVZIO.
- EVZIO [prescribing information]. Richmond, VA: kaleo, Inc.; 2016.
- Centers for Disease Control and Prevention. CDC Wonder: About multiple causes of death, 1999-2016. http://wonder.cdc.gov/mcd-icd10.html. Accessed January 25, 2018.
- Allen JD, Casavant MJ, Spiller HA, Thipalak C, Hodges NL, Smith GA. Prescription opioid exposures among children and adolescents in the United States: 2000-2015. Pediatrics. 2017;139(4):e20163382.
- Dunn KM, Saunders KW, Rutter CM, et al. Overdose and prescribed opioids: associations among chronic non-cancer pain patients. Ann Intern Med. 2010;152(2):85-92.
- Dasgupta N, Funk MJ, Proescholdbell S, et al. Cohort study of the impact of high-dose opioid analgesics on overdose mortality. Pain Medicine. 2016;17:85-89.
- Gudin JA, Mogali S, Jones JD, Comer SD. Risks, management, and monitoring of combination opioid, benzodiazepines, and/or alcohol use. Postgrad Med. 2013;125(4):115-130.
- US Food and Drug Administration. FDA warns about serious risks and death when combining opioid pain or cough medications with benzodiazepines; requires its strongest warning. August 31, 2016. https://www.fda.gov/Drugs/DrugSafety/ucm518473.htm. Accessed May 17, 2017.
- Volkow ND, McLellan AT. Opioid abuse in chronic pain—misconceptions and mitigation strategies. N Engl J Med. 2016;374:1253-1263.
- US Department of Health & Human Services. Surgeon General’s advisory on naloxone and opioid overdose. https://www.surgeongeneral.gov/priorities/opioid-overdose-prevention/naloxoneadvisory.html. Accessed April 25, 2018.