Know the factors that increase the risk for opioid overdose

Know the factors that increase the risk for opioid overdose

Anywhere opioids are present, so is the risk for an opioid overdose1

There are risks with taking prescription opioid painkillers, even when they are taken correctly.

42,000 deaths due to opioids in 2016—40% involved prescription opioid painkillers2

~85% of deaths from opioid painkillers are accidental2

>6,000 children 0 to 5 years of age accidentally come in contact with opioids each year3

Teenagers (13-19 years of age) are the age group with the second highest number of opioid exposures among children <20 years of age3

Know the risk factors

The risk of having an opioid overdose can increase for a number of reasons:

Increasing doses

Increasing doses of opioids4,5

Medical condition

A medical condition that affects your breathing, liver, or kidneys6

Other medications

Taking opioids and drinking alcohol or taking opioids at the same time as certain anxiety and sleep medications6,7

History

Having a history of substance use disorder8

Others at risk

Having opioids in your home, which may put others at risk (eg, children or teenagers)3

That is why the Surgeon General of the United States cautioned:

“For patients currently taking high doses of opioids as prescribed for pain… knowing how to use naloxone and keeping it within reach can save a life.”9

Be EVZIO-Ready

EVZIO—an auto-injector designed to be easy to use—provides simple, on-the-spot voice and visual guidance to help those with no medical training administer naloxone during an opioid overdose.

EVZIO is not a substitute for emergency medical care.

Talk to your healthcare professional to learn more about EVZIO.

You also can call 1-855-77-EVZIO (1-855-773-8946) for more information about EVZIO.

References:

  1. EVZIO [prescribing information]. Richmond, VA: kaleo, Inc.; 2016.
  2. Centers for Disease Control and Prevention. CDC Wonder: About multiple causes of death, 1999-2016. http://wonder.cdc.gov/mcd-icd10.html. Accessed January 25, 2018.
  3. Allen JD, Casavant MJ, Spiller HA, Thipalak C, Hodges NL, Smith GA. Prescription opioid exposures among children and adolescents in the United States: 2000-2015. Pediatrics. 2017;139(4):e20163382.
  4. Dunn KM, Saunders KW, Rutter CM, et al. Overdose and prescribed opioids: associations among chronic non-cancer pain patients. Ann Intern Med. 2010;152(2):85-92.
  5. Dasgupta N, Funk MJ, Proescholdbell S, et al. Cohort study of the impact of high-dose opioid analgesics on overdose mortality. Pain Medicine. 2016;17:85-89.
  6. Gudin JA, Mogali S, Jones JD, Comer SD. Risks, management, and monitoring of combination opioid, benzodiazepines, and/or alcohol use. Postgrad Med. 2013;125(4):115-130.
  7. US Food and Drug Administration. FDA warns about serious risks and death when combining opioid pain or cough medications with benzodiazepines; requires its strongest warning. August 31, 2016. https://www.fda.gov/Drugs/DrugSafety/ucm518473.htm. Accessed May 17, 2017.
  8. Volkow ND, McLellan AT. Opioid abuse in chronic pain—misconceptions and mitigation strategies. N Engl J Med. 2016;374:1253-1263.
  9. US Department of Health & Human Services. Surgeon General’s advisory on naloxone and opioid overdose. https://www.surgeongeneral.gov/priorities/opioid-overdose-prevention/naloxoneadvisory.html. Accessed April 25, 2018.

INDICATION

What is EVZIO?

EVZIO is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

EVZIO is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of EVZIO, even if the person wakes up.

EVZIO is safe and effective in children for known or suspected opioid overdose.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about EVZIO?

EVZIO is used to temporarily reverse the effects of opioid medicines. The medicine in EVZIO has no effect in people who are not taking opioid medicines. Always carry EVZIO with you in case of an opioid emergency.

Who should not use EVZIO?

Do not use EVZIO if you are allergic to naloxone hydrochloride or any of the ingredients in EVZIO.

What are the ingredients in EVZIO?

Active ingredient: naloxone hydrochloride
Inactive ingredients: sodium chloride, hydrochloric acid to adjust pH, and water

What should I tell my healthcare provider before using EVZIO?

Tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of EVZIO?

EVZIO may cause serious side effects, including:

Common side effects of EVZIO include dizziness and injection site redness.

These are not all of the possible side effects of EVZIO. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click for full Prescribing Information and Patient Information.

What is EVZIO?

EVZIO is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond. EVZIO is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of EVZIO, even if the person wakes up. EVZIO is safe and effective in children for known or suspected opioid overdose.

Important Safety Information

What is the most important information I should know about EVZIO?

EVZIO is used to temporarily reverse the effects of opioid medicines. The medicine in EVZIO has no effect in people who are not taking opioid medicines. Always carry EVZIO with you in case of an opioid emergency.

INDICATION

What is EVZIO?

EVZIO is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

EVZIO is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of EVZIO, even if the person wakes up.

EVZIO is safe and effective in children for known or suspected opioid overdose.