Anywhere opioids are present there may be a risk of opioid overdose1-4
There may be risks with taking prescription opioid painkillers, even when they are taken correctly.2,5
Watch this video to learn more about the risk factors associated with opioid overdose and find out how EVZIO can help.
47,600 deaths due to opioids in 20174
~90% of deaths due to opioids were accidental in 20174
>6,000 children 0 to 5 years of age experienced an accidental opioid exposure each year6*
Teenagers (ages 13-19) represented the age group with the second highest number of opioid exposures among children <20 years of age6*
Know the risk factors
The risk of having an opioid overdose can increase for a number of reasons:
Increasing doses of opioids7,8
Having a medical condition that affects your breathing (eg, COPD), liver, or kidneys9
Taking opioids and drinking alcohol or taking opioids at the same time as certain anxiety and sleep medications9,10
Having a history of substance use disorder11
Having opioids in your home, which may put others at risk (eg, children or teenagers)6
That is why the Surgeon General of the United States recommended:
“For patients currently taking high doses of opioids as prescribed for pain… knowing how to use naloxone and keeping it within reach can save a life.”5
EVZIO—an auto-injector designed to be easy to use—provides simple, on-the-spot voice and visual guidance to help those with no medical training administer naloxone during an opioid overdose.
EVZIO is not a substitute for emergency medical care.
Talk to your healthcare professional to learn more about EVZIO.
You also can call 1-855-77-EVZIO (1-855-773-8946) for more information about EVZIO.
- EVZIO [prescribing information]. Richmond, VA: kaleo, Inc.; 2016.
- Substance Abuse and Mental Health Services Administration. SAMHSA Opioid Overdose Prevention Toolkit. HHS Publication No. (SMA) 16-4742. Rockville, MD: Substance Abuse and Mental Health Services Administration, 2018.
- Federation of State Medical Boards. Guidelines for the chronic use of opioids. https://www.fsmb.org/siteassets/advocacy/policies/opioid_guidelines_as_adopted_april-2017_final.pdf. Accessed January 28, 2019.
- Centers for Disease Control and Prevention. CDC Wonder: About multiple causes of death, 1999-2017. http://wonder.cdc.gov/mcd-icd10.html. Accessed January 28, 2019.
- US Department of Health & Human Services. Surgeon General’s advisory on naloxone and opioid overdose. https://www.surgeongeneral.gov/priorities/opioid-overdose-prevention/naloxone-advisory.html. Accessed January 28, 2019.
- Allen JD, Casavant MJ, Spiller HA, Thipalak C, Hodges NL, Smith GA. Prescription opioid exposures among children and adolescents in the United States: 2000-2015. Pediatrics. 2017;139(4):e20163382.
- Dunn KM, Saunders KW, Rutter CM, et al. Overdose and prescribed opioids: associations among chronic non-cancer pain patients. Ann Intern Med. 2010;152(2):85-92.
- Dasgupta N, Funk MJ, Proescholdbell S, et al. Cohort study of the impact of high-dose opioid analgesics on overdose mortality. Pain Medicine. 2016;17:85-89.
- Gudin JA, Mogali S, Jones JD, Comer SD. Risks, management, and monitoring of combination opioid, benzodiazepines, and/or alcohol use. Postgrad Med. 2013;125(4):115-130.
- US Food and Drug Administration. FDA warns about serious risks and death when combining opioid pain or cough medications with benzodiazepines; requires its strongest warning. August 31, 2016. https://www.fda.gov/Drugs/DrugSafety/ucm518473.htm. Accessed January 28, 2019.
- Volkow ND, McLellan AT. Opioid abuse in chronic pain—misconceptions and mitigation strategies. N Engl J Med. 2016;374:1253-1263.