Know the Signs and Symptoms

Know the Signs and Symptoms

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ACT FAST! Time matters during an opioid overdose

  • Breathing problems caused by an opioid overdose can be life-threatening1,2
  • Severe and permanent brain damage can occur after 4 to 5 minutes without oxygen3
  • 13 minutes = average national EMS response time4

EMS may be too late. Ensure you know the symptoms and have naloxone on hand.

What to look for:

Signs and symptoms of an overdose may include1:

Sleepy

Unusual sleepiness and you are not able to awaken the person with a loud voice or rubbing firmly on the middle of their chest (sternum)

Breathe

Breathing problems including slow or shallow breathing in someone difficult to awaken or they look like they are not breathing

Pupil

The black circle in the center of the colored part of the eye (pupil) is very small, sometimes called “pinpoint pupils” in someone difficult to awaken

Lips

Fingernails or lips turning blue/purple

Heartbeat

Slow heartbeat and/or low blood pressure

Only a few symptoms may be present. Symptoms can get worse quickly and can be life-threatening.

Seek emergency medical care immediately after use.

Talk to your healthcare professional to learn more about EVZIO.

You also can call 1-855-77-EVZIO (1-855-773-8946) for more information about EVZIO.

References:

  1. Substance Abuse and Mental Health Services Administration. SAMHSA Opioid Overdose Prevention Toolkit. HHS Publication No. (SMA) 16-4742. Rockville, MD: Substance Abuse and Mental Health Services Administration, 2016.
  2. Lynn RR, Galinkin JL. Naloxone dosage for opioid reversal: Current evidence and clinical implications. Ther Adv Drug Saf. 2018;9(1):63-88.
  3. Agamanolis DP. Cerebral ischemia and stroke. http://neuropathology-web.org/chapter2/chapter2aHIE.html. Accessed April 28, 2018.
  4. National EMS Information System (NEMSIS). https://nemsis.org/view-reports/public-reports/ems-data-explorer/. Accessed November 29, 2017.

INDICATION

What is EVZIO?

EVZIO is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

EVZIO is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of EVZIO, even if the person wakes up.

EVZIO is safe and effective in children for known or suspected opioid overdose.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about EVZIO?

EVZIO is used to temporarily reverse the effects of opioid medicines. The medicine in EVZIO has no effect in people who are not taking opioid medicines. Always carry EVZIO with you in case of an opioid emergency.

Who should not use EVZIO?

Do not use EVZIO if you are allergic to naloxone hydrochloride or any of the ingredients in EVZIO.

What are the ingredients in EVZIO?

Active ingredient: naloxone hydrochloride
Inactive ingredients: sodium chloride, hydrochloric acid to adjust pH, and water

What should I tell my healthcare provider before using EVZIO?

Tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of EVZIO?

EVZIO may cause serious side effects, including:

Common side effects of EVZIO include dizziness and injection site redness.

These are not all of the possible side effects of EVZIO. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click for full Prescribing Information and Patient Information.

What is EVZIO?

EVZIO is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond. EVZIO is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of EVZIO, even if the person wakes up. EVZIO is safe and effective in children for known or suspected opioid overdose.

Important Safety Information

What is the most important information I should know about EVZIO?

EVZIO is used to temporarily reverse the effects of opioid medicines. The medicine in EVZIO has no effect in people who are not taking opioid medicines. Always carry EVZIO with you in case of an opioid emergency.

INDICATION

What is EVZIO?

EVZIO is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

EVZIO is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of EVZIO, even if the person wakes up.

EVZIO is safe and effective in children for known or suspected opioid overdose.