Know the factors that increase the risk for opioid overdose

Know the factors that increase the risk for opioid overdose

Anywhere opioids are present, so is the risk for an opioid overdose1

Deaths due to opioid overdose have continued to increase.2-4

Deaths due to opioid overdose are a growing public health crisis that affects people of all races, genders, socioeconomic levels, and geographic regions.

Over 115 people a day—one every 12.5 minutes—died due to opioid overdoses in 2016.5

Know the risks

Be aware that factors in a person's everyday life can increase the risk for experiencing or witnessing an opioid overdose.

People, places, and things

People, places, and things (eg, a restaurant, a film, an image, celebratory events)6,7

Stressful life-events

Stressful life-events (eg, death of a loved one, divorce, loss of a job)6,7

Surroundings

During or after treatment when you return to the circle of friends and surroundings where you used opioids before6,7

Also know that certain people have higher risk for opioid overdose, including those who8,9:

Alcohol drugs
  • Misuse prescription opioids (like oxycodone) or use heroin or other illicit opioids (like fentanyl or carfentanil)
  • Were just discharged from detoxification or a treatment facility without medication treatment or stop taking medication treatment
  • Recently received emergency medical care for an opioid overdose
Released
  • Were recently released from prison and have a history of opioid misuse or addiction
  • Use opioids along with alcohol or certain medications (like benzodiazepines)

Be EVZIO-Ready

EVZIO—an auto-injector designed to be easy to use—provides simple, on-the-spot voice and visual guidance to help those with no medical training administer naloxone during an opioid overdose.

EVZIO is not a substitute for emergency medical care.

Talk to your healthcare professional to learn more about EVZIO.

You also can call 1-855-77-EVZIO (1-855-773-8946) for more information about EVZIO.

References:

  1. EVZIO [prescribing information]. Richmond, VA: kaleo, Inc.; 2016.
  2. Centers for Disease Control and Prevention. Today’s heroin epidemic: overdose prevention. https://www.cdc.gov/drugoverdose/opioids/heroin.html. Accessed April 27, 2018.
  3. Centers for Disease Control and Prevention. Drug overdose. https://www.cdc.gov/drugoverdose/data/index.html. Accessed May 15, 2018.
  4. U.S. Department of Health and Human Services. What is the U.S. opioid epidemic? https://www.hhs.gov/opioids/about-the-epidemic/index.html. Accessed May 15, 2018.
  5. Centers for Disease Control and Prevention. CDC Wonder: About multiple causes of death, 1999-2016. http://wonder.cdc.gov/mcd-icd10.html. Accessed January 25, 2018.
  6. National Institute on Drug Abuse. Drugs, brains, and behavior: The science of addiction. NIH Pub No.14-5605. Printed April 2007, Revised July 2014. https://d14rmgtrwzf5a.cloudfront.net/sites/default/files/soa_2014.pdf. Accessed May 17, 2018.
  7. Data on file. Richmond, VA: kaleo Inc; 2018.
  8. US Department of Health & Human Services. Surgeon General’s advisory on naloxone and opioid overdose. https://www.surgeongeneral.gov/priorities/opioid-overdose-prevention/ naloxoneadvisory.html. Accessed April 25, 2018.
  9. World Health Organization. Management of substance abuse. Information sheet on opioid overdose. November 2014. http://www.who.int/substance_abuse/information-sheet/en/. Accessed April 27, 2018.

INDICATION

What is EVZIO?

EVZIO is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

EVZIO is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of EVZIO, even if the person wakes up.

EVZIO is safe and effective in children for known or suspected opioid overdose.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about EVZIO?

EVZIO is used to temporarily reverse the effects of opioid medicines. The medicine in EVZIO has no effect in people who are not taking opioid medicines. Always carry EVZIO with you in case of an opioid emergency.

Who should not use EVZIO?

Do not use EVZIO if you are allergic to naloxone hydrochloride or any of the ingredients in EVZIO.

What are the ingredients in EVZIO?

Active ingredient: naloxone hydrochloride
Inactive ingredients: sodium chloride, hydrochloric acid to adjust pH, and water

What should I tell my healthcare provider before using EVZIO?

Tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of EVZIO?

EVZIO may cause serious side effects, including:

Common side effects of EVZIO include dizziness and injection site redness.

These are not all of the possible side effects of EVZIO. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click for full Prescribing Information and Patient Information.

What is EVZIO?

EVZIO is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond. EVZIO is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of EVZIO, even if the person wakes up. EVZIO is safe and effective in children for known or suspected opioid overdose.

Important Safety Information

What is the most important information I should know about EVZIO?

EVZIO is used to temporarily reverse the effects of opioid medicines. The medicine in EVZIO has no effect in people who are not taking opioid medicines. Always carry EVZIO with you in case of an opioid emergency.

INDICATION

What is EVZIO?

EVZIO is a prescription medicine used in adults and children for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

EVZIO is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after the first dose of EVZIO, even if the person wakes up.

EVZIO is safe and effective in children for known or suspected opioid overdose.