In an opioid overdose, time matters
In 2017, there were 47,600 deaths due to opioids, and more than half of opioid overdoses occurred outside a medical setting.1 As those on the front line of emergencies, you know the importance of access to take-home naloxone. A majority of states have enacted Good Samaritan legislation that is supportive of administering aid for opioid-related overdoses, and some states even go as far as providing immunity for events leading up to assisting in such a crisis, reinforcing the importance and need for take-home naloxone.2
Anywhere opioids are present there may be a risk of opioid overdose.1,3-5
EVZIO—an auto-injector designed to be easy to use—provides simple, on-the-spot voice and visual guidance to help those most likely to be the first to witness an opioid overdose administer naloxone.1,6 EVZIO is not a substitute for emergency medical care. The use of EVZIO may result in symptoms of acute opioid withdrawal.
Take-home naloxone options available
Naloxone Delivery Device preference7
- 70.5% preferred EVZIO
- 25% preferred Narcan® Nasal Spray
- 4.5% had no preference
Adult participants overall preferred EVZIO vs. NARCAN nasal spray (P<0.01) in a simulated opioid overdose usability study (N=44).
EVZIO is tested to withstand the rigors of use outside a hospital environment7
Tested up to 6 months as high as 104°F (40°C)
Withstands up to 300-pound force to the device
Tested with window cleaner, soap, bleach, acetone, nail polish, hand sanitizer, stain remover liquid, and hydrogen peroxide
Protects against water penetration (eg, heavy rainfall) and delivers its intended dose. Tested by exposing the auto-injector to falling drops of water at a rate of 1 mm/min for a 10-minute period
Always have EVZIO on hand—you never know when you will need it. Remember, do not leave EVZIO in your car because extreme temperatures can affect your device. A great place to keep EVZIO is in your pocket or in your bag.
Talk to your kaleo representative to learn more about EVZIO.
You also can call 1-855-77-EVZIO (1-855-773-8946) for more information about EVZIO.
- Centers for Disease Control and Prevention. CDC Wonder: About multiple causes of death, 1999-2017. http://wonder.cdc.gov/mcd-icd10.html. Accessed January 28, 2019.
- National conference of state legislatures. Drug overdose immunity and good Samaritan laws. 2017. http://www.ncsl.org/research/civil-and-criminal-justice/drugoverdose-immunity-good-samaritan-laws.aspx. Accessed January 28, 2019.
- EVZIO [prescribing information]. Richmond, VA: kaleo, Inc.
- Substance Abuse and Mental Health Services Administration. SAMHSA Opioid Overdose Prevention Toolkit. HHS Publication No. (SMA) 16-4742. Rockville, MD: Substance Abuse and Mental Health Services Administration, 2018.
- Federation of State Medical Boards. Guidelines for the chronic use of opioid analgesics. April 2017. https://www.fsmb.org/siteassets/advocacy/policies/opioid_guidelines_as_adopted_april-2017_final.pdf. Accessed January 25, 2019.
- Adams JM. Increasing naloxone awareness and use: The role of health care practitioners. JAMA. 2018;319(20):2073-2074.
- Data on file. Richmond, VA: kaleo, Inc.
- NARCAN [prescribing information]. Radnor, PA. Adapt Pharma, Inc. 2017.
- Raffa RB, Taylor R JR, Pergolizzie JV JR, Nalamachu S, Edwards ES, Edwards ET. Application of human factors engineering (HFE) to the design of a naloxone auto-injector for the treatment of opioid emergencies. Drug Deliv and Transl Res. 2017;(7):1-10.